If you’re not already familiar (and, frankly, are the kind of person who is weird enough to be subscribed to Macroscience), I highly recommend that you immediately stop what you’re doing and visit the Wikipedia page for “long-term experiment”. Then, check out Sam Arbesman’s
Long Science
Another idea to increase the temporal scope of an experiment is to run it in parallel.
An effort like Sebastian Cocioba's plan to democratize and desktop-ify the LTEE experiment is a good example: https://experiment.com/projects/affordable-and-accessible-experimental-evolution-for-the-classroom